Structural analyses of sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.

Hargrove TY, Friggeri L, Wawrzak Z, Qi A, Hoekstra WJ, Schotzinger RJ, York JD, Guengerich FP, Lepesheva GI
J Biol Chem. 2017 292 (16): 6728-6743

PMID: 28258218 · PMCID: PMC5399120 · DOI:10.1074/jbc.M117.778308

MeSH Terms (17)

Animals Antifungal Agents Azoles Candida albicans Crystallization Fungal Proteins Heme Humans Kinetics Ligands Microbial Sensitivity Tests Protein Binding Protein Conformation Protons Rats Sterol 14-Demethylase Sterols

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