Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer.

Wang C, Gong G, Sheh A, Muthupalani S, Bryant EM, Puglisi DA, Holcombe H, Conaway EA, Parry NAP, Bakthavatchalu V, Short SP, Williams CS, Wogan GN, Tannenbaum SR, Fox JG, Horwitz BH
Mucosal Immunol. 2017 10 (6): 1504-1517

PMID: 28198364 · PMCID: PMC5557711 · DOI:10.1038/mi.2017.9

MeSH Terms (20)

Animals Antibodies, Blocking Colitis, Ulcerative Colon Colonic Neoplasms Disease Models, Animal DNA-Binding Proteins DNA Breaks, Double-Stranded Helicobacter hepaticus Helicobacter Infections Humans Inflammation Interleukins Macrophages, Peritoneal Mice Mice, 129 Strain Mice, Knockout Neoplasms Nitric Oxide Nitric Oxide Synthase Type II

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