WNK Kinase Signaling in Ion Homeostasis and Human Disease.

Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT
Cell Metab. 2017 25 (2): 285-299

PMID: 28178566 · DOI:10.1016/j.cmet.2017.01.007

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

Copyright © 2017 Elsevier Inc. All rights reserved.

MeSH Terms (10)

Amino Acid Sequence Animals Biological Transport Cell Size Disease Homeostasis Humans Ions Protein-Serine-Threonine Kinases Signal Transduction

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