Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain.

Guedes-da-Silva FH, Batista DG, Da Silva CF, De Araújo JS, Pavão BP, Simões-Silva MR, Batista MM, Demarque KC, Moreira OC, Britto C, Lepesheva GI, Soeiro MN
Antimicrob Agents Chemother. 2017 61 (4)

PMID: 28167559 · PMCID: PMC5365685 · DOI:10.1128/AAC.02098-16

MeSH Terms (22)

14-alpha Demethylase Inhibitors Animals Chagas Disease Cyclophosphamide Cytochrome P-450 Enzyme System Disease Models, Animal Drug Administration Schedule Female Gene Expression Humans Imidazoles Immunosuppressive Agents Male Mice Models, Molecular Nitroimidazoles Oxadiazoles Parasite Load Recurrence Survival Analysis Trypanocidal Agents Trypanosoma cruzi

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