ERAD-icating mutant insulin promotes functional insulin secretion.

Moore DJ
Sci Transl Med. 2017 9 (373)

PMID: 28100837 · DOI:10.1126/scitranslmed.aal4995

Overexpression of a chaperone protein liberates functional insulin from a misfolded mutant partner to improve insulin secretion.

Copyright © 2017, American Association for the Advancement of Science.

MeSH Terms (6)

Endoplasmic Reticulum Endoplasmic Reticulum-Associated Degradation Insulin Insulin Secretion Proinsulin Protein Folding

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