Reduced effects of age on dopamine D2 receptor levels in physically active adults.

Dang LC, Castrellon JJ, Perkins SF, Le NT, Cowan RL, Zald DH, Samanez-Larkin GR
Neuroimage. 2017 148: 123-129

PMID: 28089678 · PMCID: PMC5344739 · DOI:10.1016/j.neuroimage.2017.01.018

Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.

Copyright © 2017 Elsevier Inc. All rights reserved.

MeSH Terms (18)

Adult Aged Aged, 80 and over Aging Benzamides Brain Cross-Sectional Studies Exercise Female Humans Magnetic Resonance Imaging Male Middle Aged Positron-Emission Tomography Radiopharmaceuticals Receptors, Dopamine D2 Receptors, Dopamine D3 Young Adult

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