Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers.

Gu M, Shao NY, Sa S, Li D, Termglinchan V, Ameen M, Karakikes I, Sosa G, Grubert F, Lee J, Cao A, Taylor S, Ma Y, Zhao Z, Chappell J, Hamid R, Austin ED, Gold JD, Wu JC, Snyder MP, Rabinovitch M
Cell Stem Cell. 2017 20 (4): 490-504.e5

PMID: 28017794 · PMCID: PMC5500296 · DOI:10.1016/j.stem.2016.08.019

MeSH Terms (21)

Base Sequence Bone Morphogenetic Protein 4 Bone Morphogenetic Protein Receptors, Type II Cell Adhesion Cell Movement Cell Shape Cell Survival Endothelial Cells Gene Editing Gene Expression Regulation Heterozygote Humans Hypertension, Pulmonary Induced Pluripotent Stem Cells Mutation Neovascularization, Physiologic p38 Mitogen-Activated Protein Kinases Phosphorylation Sequence Analysis, RNA Signal Transduction Smad Proteins

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