Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.

Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A
Cancer Cell. 2017 31 (1): 142-156

PMID: 28017613 · PMCID: PMC5363285 · DOI:10.1016/j.ccell.2016.11.011

MeSH Terms (12)

Age Factors Animals Apoptosis bcl-2 Homologous Antagonist-Killer Protein bcl-2-Associated X Protein Doxorubicin Humans Mice Mitochondria Neoplasms Organ Specificity Proto-Oncogene Proteins c-myc

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