Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.

Cowen SD, Russell D, Dakin LA, Chen H, Larsen NA, Godin R, Throner S, Zheng X, Molina A, Wu J, Cheung T, Howard T, Garcia-Arenas R, Keen N, Pendleton CS, Pietenpol JA, Ferguson AD
J Med Chem. 2016 59 (24): 11079-11097

PMID: 28002961 · DOI:10.1021/acs.jmedchem.6b01303

MeSH Terms (10)

Cell Line, Tumor Cell Proliferation Dose-Response Relationship, Drug Drug Design Enzyme Inhibitors HCT116 Cells Histone-Lysine N-Methyltransferase Humans Molecular Structure Structure-Activity Relationship

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