Murine transforming growth factor-beta 2 cDNA sequence and expression in adult tissues and embryos.

Miller DA, Lee A, Pelton RW, Chen EY, Moses HL, Derynck R
Mol Endocrinol. 1989 3 (7): 1108-14

PMID: 2797004 · DOI:10.1210/mend-3-7-1108

Murine transforming growth factor-beta 2 (TGF-beta 2) cDNAs were isolated from cDNA libraries derived from a differentiated murine embryonic carcinoma cell line, PCC3. The composite cDNA sequence is 4267 nucleotides long, including a 1217 nucleotides 5'-untranslated sequence, and encodes a murine TGF-beta 2 precursor of 414 amino acids with 96% identity to its human counterpart. Several consensus polyadenylation sequences are present in the 1807 nucleotides 3'-untranslated sequence. Five TGF-beta 2 mRNA species are observed in the developing mouse fetus and they show different patterns of expression during development. TGF-beta 2 mRNA expression was also examined in adult mouse tissues, in which four of the five RNA species were observed. TGF-beta 2 mRNAs were present in all adult mouse tissues examined, except liver, and was most abundant in placenta, the male submaxillary gland and lung. The patterns of expression suggest a physiological role for TGF-beta 2 both in embryonic development and in the maintenance of adult tissues.

MeSH Terms (16)

Amino Acid Sequence Animals Base Sequence Blotting, Northern DNA Probes Embryonic and Fetal Development Fetus Humans Mice Molecular Sequence Data Protein Precursors Proteins RNA, Messenger Sequence Homology, Nucleic Acid Transforming Growth Factor beta Transforming Growth Factors

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