Challenges in the development of an M PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.

Wood MR, Noetzel MJ, Poslusney MS, Melancon BJ, Tarr JC, Lamsal A, Chang S, Luscombe VB, Weiner RL, Cho HP, Bubser M, Jones CK, Niswender CM, Wood MW, Engers DW, Brandon NJ, Duggan ME, Conn PJ, Bridges TM, Lindsley CW
Bioorg Med Chem Lett. 2017 27 (2): 171-175

PMID: 27939174 · PMCID: PMC5340297 · DOI:10.1016/j.bmcl.2016.11.086

MeSH Terms (9)

Animals Humans Ligands Nucleoside Transport Proteins Pyridazines Rats, Sprague-Dawley Receptor, Muscarinic M4 Structure-Activity Relationship Thiophenes

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