IQGAP1 makes PI(3)K signalling as easy as PIP, PIP, PIP.

Rameh LE, Mackey AM
Nat Cell Biol. 2016 18 (12): 1263-1265

PMID: 27897158 · DOI:10.1038/ncb3440

Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P synthesis to facilitate Akt activation in response to extracellular stimuli.

MeSH Terms (9)

Animals Humans Models, Biological Neoplasms Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Phosphorylation ras GTPase-Activating Proteins Signal Transduction

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