SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer.

Lu W, Liu S, Li B, Xie Y, Izban MG, Ballard BR, Sathyanarayana SA, Adunyah SE, Matusik RJ, Chen Z
Oncogene. 2017 36 (10): 1364-1373

PMID: 27869166 · PMCID: PMC5724960 · DOI:10.1038/onc.2016.300

MeSH Terms (18)

Animals Cell Line, Tumor Disease Models, Animal Enhancer of Zeste Homolog 2 Protein Gene Knockout Techniques Histones Humans Lysine Male Mice Prostate Prostatic Neoplasms Protein Stability PTEN Phosphohydrolase S-Phase Kinase-Associated Proteins TNF Receptor-Associated Factor 6 Tumor Suppressor Protein p53 Ubiquitination

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