Iron acquisition pathways and colonization of the inflamed intestine by Salmonella enterica serovar Typhimurium.

Costa LF, Mol JP, Silva AP, Macêdo AA, Silva TM, Alves GE, Winter S, Winter MG, Velazquez EM, Byndloss MX, Bäumler AJ, Tsolis RM, Paixão TA, Santos RL
Int J Med Microbiol. 2016 306 (8): 604-610

PMID: 27760693 · PMCID: PMC5140723 · DOI:10.1016/j.ijmm.2016.10.004

Salmonella enterica serotype Typhimurium is able to expand in the lumen of the inflamed intestine through mechanisms that have not been fully resolved. Here we utilized streptomycin-pretreated mice and dextran sodium sulfate (DSS)-treated mice to investigate how pathways for S. Typhimurium iron acquisition contribute to pathogen expansion in the inflamed intestine. Competitive infection with an iron uptake-proficient S. Typhimurium strain and mutant strains lacking tonB feoB, feoB, tonB or iroN in streptomycin pretreated mice demonstrated that ferric iron uptake requiring IroN and TonB conferred a fitness advantage during growth in the inflamed intestine. However, the fitness advantage conferred by ferrous iron uptake mechanisms was independent of inflammation and was only apparent in models where the normal microbiota composition had been disrupted by antibiotic treatment.

Copyright © 2016 Elsevier GmbH. All rights reserved.

MeSH Terms (14)

Animals Bacterial Proteins Cattle Disease Models, Animal Female Gastroenteritis Intestines Iron Male Metabolic Networks and Pathways Mice, Inbred C57BL Salmonella Infections Salmonella typhimurium Virulence Factors

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