Local Delivery of PHD2 siRNA from ROS-Degradable Scaffolds to Promote Diabetic Wound Healing.

Martin JR, Nelson CE, Gupta MK, Yu F, Sarett SM, Hocking KM, Pollins AC, Nanney LB, Davidson JM, Guelcher SA, Duvall CL
Adv Healthc Mater. 2016 5 (21): 2751-2757

PMID: 27717176 · PMCID: PMC5152672 · DOI:10.1002/adhm.201600820

Small interfering RNA (siRNA) delivered from reactive oxygen species-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) scaffolds implanted in diabetic wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2, thereby increasing the expression of progrowth genes and increasing vasculature, proliferating cells, and tissue development in diabetic wounds.

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

MeSH Terms (14)

Animals Cell Proliferation Diabetes Mellitus Hypoxia-Inducible Factor-Proline Dioxygenases Male Neovascularization, Physiologic Procollagen-Proline Dioxygenase Rats Rats, Sprague-Dawley Reactive Oxygen Species RNA, Small Interfering Tissue Engineering Tissue Scaffolds Wound Healing

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