Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization.

Uddin MJ, Moore CE, Crews BC, Daniel CK, Ghebreselasie K, McIntyre JO, Marnett LJ, Jayagopal A
J Biomed Opt. 2016 21 (9): 90503

PMID: 27626899 · PMCID: PMC5021825 · DOI:10.1117/1.JBO.21.9.090503

Ocular angiogenesis is a blinding complication of age-related macular degeneration and other retinal vascular diseases. Clinical imaging approaches to detect inflammation prior to the onset of neovascularization in these diseases may enable early detection and timely therapeutic intervention. We demonstrate the feasibility of a previously developed cyclooxygenase-2 (COX-2) targeted molecular imaging probe, fluorocoxib A, for imaging retinal inflammation in a mouse model of laser-induced choroidal neovascularization. This imaging probe exhibited focal accumulation within laser-induced neovascular lesions, with minimal detection in proximal healthy tissue. The selectivity of the probe for COX-2 was validated

MeSH Terms (9)

Animals Choroidal Neovascularization Cyclooxygenase 2 Feasibility Studies Image Processing, Computer-Assisted Indoles Mice Optical Imaging Rhodamines

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