A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.

Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE, Aman MJ, Dye JM, Lai JR, Chandran K
Science. 2016 354 (6310): 350-354

PMID: 27608667 · PMCID: PMC5647781 · DOI:10.1126/science.aag3267

MeSH Terms (20)

Animals Antibodies, Bispecific Antibodies, Monoclonal Antibodies, Neutralizing Antibodies, Viral Binding Sites Carrier Proteins Cell Line, Tumor Ebolavirus Endosomes Hemorrhagic Fever, Ebola Humans Immunotherapy Intracellular Signaling Peptides and Proteins Membrane Glycoproteins Mice Mice, Inbred BALB C Receptors, Virus Viral Envelope Proteins Virus Internalization

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