Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension.

Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY
J Clin Invest. 2016 126 (9): 3313-35

PMID: 27548520 · PMCID: PMC5004943 · DOI:10.1172/JCI86387

MeSH Terms (26)

Adolescent Adult Aged Animals Child Collagen Endothelial Cells Extracellular Matrix Female Glutamic Acid Humans Hypertension, Pulmonary Infant Intracellular Signaling Peptides and Proteins Male Mechanotransduction, Cellular Middle Aged Myocytes, Smooth Muscle Phosphoproteins Rats Rats, Sprague-Dawley Trans-Activators Transcriptional Coactivator with PDZ-Binding Motif Proteins Transcription Factors Vascular Stiffness Young Adult

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