The Role of the Microbiome in Gastrointestinal Cancer.

Wroblewski LE, Peek RM, Coburn LA
Gastroenterol Clin North Am. 2016 45 (3): 543-56

PMID: 27546848 · PMCID: PMC4994977 · DOI:10.1016/j.gtc.2016.04.010

Humans are host to complex microbial communities previously termed normal flora and largely overlooked. However, resident microbes contribute to both health and disease. Investigators are beginning to define microbes that contribute to the development of gastrointestinal malignancies and the mechanisms by which this occurs. Resident microbes can induce inflammation, leading to cell proliferation and altered stem cell dynamics, which can lead to alterations in DNA integrity and immune regulation and promote carcinogenesis. Studies in human patients and rodent models of cancer have identified alterations in the microbiota of the stomach, esophagus, and colon that increase the risk for malignancy.

Published by Elsevier Inc.

MeSH Terms (19)

Adenocarcinoma Animals Carcinogenesis Cell Proliferation Colonic Polyps Colorectal Neoplasms Diet Disease Models, Animal Esophageal Neoplasms Gastrointestinal Microbiome Gastrointestinal Neoplasms Gastrointestinal Tract Helicobacter Infections Helicobacter pylori Humans Inflammation Microbiota Stem Cells Stomach Neoplasms

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