Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.

Hacker KE, Fahey CC, Shinsky SA, Chiang YJ, DiFiore JV, Jha DK, Vo AH, Shavit JA, Davis IJ, Strahl BD, Rathmell WK
J Biol Chem. 2016 291 (40): 21283-21295

PMID: 27528607 · PMCID: PMC5076534 · DOI:10.1074/jbc.M116.739375

MeSH Terms (12)

Enzyme Stability Histone-Lysine N-Methyltransferase Histones Humans Methylation Methyltransferases Mutation Neoplasm Proteins Neoplasms Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Structure-Activity Relationship

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