Autonomic Blockade Reverses Endothelial Dysfunction in Obesity-Associated Hypertension.

Gamboa A, Figueroa R, Paranjape SY, Farley G, Diedrich A, Biaggioni I
Hypertension. 2016 68 (4): 1004-10

PMID: 27528067 · PMCID: PMC5016238 · DOI:10.1161/HYPERTENSIONAHA.116.07681

Impaired nitric oxide (NO) vasodilation (endothelial dysfunction) is associated with obesity and thought to be a factor in the development of hypertension. We previously found that NO synthesis inhibition had similar pressor effects in obese hypertensives compared with healthy control during autonomic blockade, suggesting that impaired NO vasodilation is secondary to sympathetic activation. We tested this hypothesis by determining the effect of autonomic blockade (trimethaphan 4 mg/min IV) on NO-mediated vasodilation (increase in forearm blood flow to intrabrachial acetylcholine) compared with endothelial-independent vasodilation (intrabrachial sodium nitroprusside) in obese hypertensive subjects (30
© 2016 American Heart Association, Inc.

MeSH Terms (18)

Autonomic Nerve Block Blood Pressure Determination Body Mass Index Comorbidity Cross-Over Studies Disease Progression Endothelium, Vascular Female Follow-Up Studies Humans Hypertension Male Middle Aged Nitric Oxide Nitroprusside Obesity Risk Assessment Severity of Illness Index

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