Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor.

Adeniji A, Uddin MJ, Zang T, Tamae D, Wangtrakuldee P, Marnett LJ, Penning TM
J Med Chem. 2016 59 (16): 7431-44

PMID: 27486833 · PMCID: PMC5149398 · DOI:10.1021/acs.jmedchem.6b00160

MeSH Terms (12)

3-Hydroxysteroid Dehydrogenases Aldo-Keto Reductase Family 1 Member C3 Butyrates Cell Line, Tumor Dose-Response Relationship, Drug Drug Discovery Enzyme Inhibitors Humans Hydroxyprostaglandin Dehydrogenases Molecular Structure Naphthalenes Structure-Activity Relationship

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