Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.

Joyce MG, Zhang B, Ou L, Chen M, Chuang GY, Druz A, Kong WP, Lai YT, Rundlet EJ, Tsybovsky Y, Yang Y, Georgiev IS, Guttman M, Lees CR, Pancera M, Sastry M, Soto C, Stewart-Jones GBE, Thomas PV, Van Galen JG, Baxa U, Lee KK, Mascola JR, Graham BS, Kwong PD
Nat Struct Mol Biol. 2016 23 (9): 811-820

PMID: 27478931 · PMCID: PMC5016229 · DOI:10.1038/nsmb.3267

MeSH Terms (16)

Animals Crystallography, X-Ray Female Glycoproteins HEK293 Cells Humans Male Mice, Inbred C57BL Models, Molecular Protein Engineering Protein Stability Respiratory Syncytial Viruses Respiratory Syncytial Virus Infections Vaccination Viral Fusion Proteins Viral Vaccines

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