Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.

Wood MR, Noetzel MJ, Tarr JC, Rodriguez AL, Lamsal A, Chang S, Foster JJ, Smith E, Chase P, Hodder PS, Engers DW, Niswender CM, Brandon NJ, Wood MW, Duggan ME, Conn PJ, Bridges TM, Lindsley CW
Bioorg Med Chem Lett. 2016 26 (17): 4282-6

PMID: 27476142 · PMCID: PMC4987221 · DOI:10.1016/j.bmcl.2016.07.042

MeSH Terms (9)

Allosteric Regulation Animals Central Nervous System Drug Discovery Humans Ketones Molecular Structure Receptor, Muscarinic M1 Structure-Activity Relationship

Connections (2)

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