Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers.

Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ
ACS Chem Neurosci. 2016 7 (9): 1201-11

PMID: 27441572 · PMCID: PMC5073817 · DOI:10.1021/acschemneuro.6b00036

MeSH Terms (20)

Allosteric Regulation Animals Antiparkinson Agents Antipsychotic Agents Apomorphine Brain Catalepsy Disease Models, Animal Dopamine Agonists Forelimb Glutamic Acid Haloperidol HEK293 Cells Humans Oxidopamine Parkinson Disease Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate Transfection

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