IRF3 promotes adipose inflammation and insulin resistance and represses browning.

Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, Tenen D, Roh HC, Kong X, Kazak L, Ahmad R, Rosen ED
J Clin Invest. 2016 126 (8): 2839-54

PMID: 27400129 · PMCID: PMC4966307 · DOI:10.1172/JCI86080

MeSH Terms (26)

3T3-L1 Cells Adipocytes Adipose Tissue Adiposity Adult Animals Blood Glucose Diet Female Gene Expression Regulation Glucose Clamp Technique Glucose Transporter Type 4 HEK293 Cells Homeostasis Humans Inflammation Insulin Resistance Interferon Regulatory Factor-3 Male Mice Mice, Transgenic Middle Aged NF-kappa B Obesity Toll-Like Receptor 3 Toll-Like Receptor 4

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