Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.

Sengmany K, Singh J, Stewart GD, Conn PJ, Christopoulos A, Gregory KJ
Neuropharmacology. 2017 115: 60-72

PMID: 27392634 · PMCID: PMC5217481 · DOI:10.1016/j.neuropharm.2016.07.001

MeSH Terms (14)

Allosteric Regulation Animals Calcium Signaling Dose-Response Relationship, Drug Drug Discovery Drug Evaluation, Preclinical Excitatory Amino Acid Agonists Excitatory Amino Acid Antagonists Female HEK293 Cells Humans MAP Kinase Signaling System Mice Receptor, Metabotropic Glutamate 5

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