Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies.

Beavers KR, Werfel TA, Shen T, Kavanaugh TE, Kilchrist KV, Mares JW, Fain JS, Wiese CB, Vickers KC, Weiss SM, Duvall CL
Adv Mater. 2016 28 (36): 7984-7992

PMID: 27383910 · PMCID: PMC5152671 · DOI:10.1002/adma.201601646

Self-assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable scaffold with high drug-cargo-loading capacity. Functionalization with a diblock polymer improves PSi nanoparticle colloidal stability, in vivo pharmacokinetics, and intracellular bioavailability through endosomal escape, enabling PNA to inhibit miR-122 in vivo.

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

MeSH Terms (13)

Animals Cell Line, Tumor Colloids Female Humans Mice MicroRNAs Nanocomposites Peptide Nucleic Acids Polymers Porosity RNAi Therapeutics Silicon

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