The intersection between asthma and acute chest syndrome in children with sickle-cell anaemia.

DeBaun MR, Strunk RC
Lancet. 2016 387 (10037): 2545-53

PMID: 27353685 · PMCID: PMC5041533 · DOI:10.1016/S0140-6736(16)00145-8

Acute chest syndrome is a frequent cause of acute lung disease in children with sickle-cell disease. Asthma is common in children with sickle-cell disease and is associated with increased incidence of vaso-occlusive pain events, acute chest syndrome episodes, and earlier death. Risk factors for asthma exacerbation and an acute chest syndrome episode are similar, and both can present with shortness of breath, chest pain, cough, and wheezing. Despite overlapping risk factors and symptoms, an acute exacerbation of asthma or an episode of acute chest syndrome are two distinct entities that need disease-specific management strategies. Although understanding has increased about asthma as a comorbidity in sickle-cell disease and its effects on morbidity, substantial gaps remain in knowledge about best management.

Copyright © 2016 Elsevier Ltd. All rights reserved.

MeSH Terms (16)

Acute Chest Syndrome Adolescent Age Distribution Anemia, Sickle Cell Anti-Bacterial Agents Asthma Bronchial Hyperreactivity Child Child, Preschool Female Humans Infant Infant, Newborn Male Risk Factors Young Adult

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