Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health.

Fontana L, Cummings NE, Arriola Apelo SI, Neuman JC, Kasza I, Schmidt BA, Cava E, Spelta F, Tosti V, Syed FA, Baar EL, Veronese N, Cottrell SE, Fenske RJ, Bertozzi B, Brar HK, Pietka T, Bullock AD, Figenshau RS, Andriole GL, Merrins MJ, Alexander CM, Kimple ME, Lamming DW
Cell Rep. 2016 16 (2): 520-530

PMID: 27346343 · PMCID: PMC4947548 · DOI:10.1016/j.celrep.2016.05.092

Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways. Our results highlight a critical role for dietary quality at the level of amino acids in the maintenance of metabolic health and suggest that diets specifically reduced in BCAAs, or pharmacological interventions in this pathway, may offer a translatable way to achieve many of the metabolic benefits of a PR diet.

Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

MeSH Terms (16)

Adipose Tissue, White Amino Acids, Branched-Chain Animals Blood Glucose Dietary Proteins Fibroblast Growth Factors Gluconeogenesis Glucose Intolerance Humans Insulin-Secreting Cells Male Mice, Inbred C57BL Middle Aged Obesity Organ Size Stress, Physiological

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