Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology.

Yamazaki H, Suemizu H, Mitsui M, Shimizu M, Guengerich FP
Chem Res Toxicol. 2016 29 (12): 1903-1911

PMID: 27337115 · PMCID: PMC5292139 · DOI:10.1021/acs.chemrestox.6b00136

MeSH Terms (10)

Activation, Metabolic Animals Chimera Cytochrome P-450 Enzyme System Humans Liver Mass Spectrometry Mice Thalidomide Toxicokinetics

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