Repurposing the Nonsteroidal Anti-inflammatory Drug Diflunisal as an Osteoprotective, Antivirulence Therapy for Staphylococcus aureus Osteomyelitis.

Hendrix AS, Spoonmore TJ, Wilde AD, Putnam NE, Hammer ND, Snyder DJ, Guelcher SA, Skaar EP, Cassat JE
Antimicrob Agents Chemother. 2016 60 (9): 5322-30

PMID: 27324764 · PMCID: PMC4997817 · DOI:10.1128/AAC.00834-16

MeSH Terms (21)

Animals Anti-Bacterial Agents Anti-Inflammatory Agents, Non-Steroidal Bacterial Proteins Bone Density Conservation Agents Cell Survival Delayed-Action Preparations Diflunisal Drug Repositioning Female Gene Expression Humans Mice Mice, Inbred C57BL Osteoblasts Osteomyelitis Primary Cell Culture Staphylococcal Infections Staphylococcus aureus Trans-Activators Treatment Outcome

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