Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design.

Hargrove TY, Friggeri L, Wawrzak Z, Sivakumaran S, Yazlovitskaya EM, Hiebert SW, Guengerich FP, Waterman MR, Lepesheva GI
J Lipid Res. 2016 57 (8): 1552-63

PMID: 27313059 · PMCID: PMC4959870 · DOI:10.1194/jlr.M069229

MeSH Terms (17)

14-alpha Demethylase Inhibitors Antifungal Agents Antineoplastic Agents Antiprotozoal Agents Catalytic Domain Cell Line, Tumor Cholestadienols Crystallography, X-Ray Drug Design Drug Screening Assays, Antitumor Humans Hydrogen Bonding Lanosterol Models, Molecular Protein Binding Protein Conformation, alpha-Helical Sterol 14-Demethylase

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