A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1.

Nnamani MC, Ganguly S, Erkenbrack EM, Lynch VJ, Mizoue LS, Tong Y, Darling HL, Fuxreiter M, Meiler J, Wagner GP
Cell Rep. 2016 15 (10): 2097-2108

PMID: 27239043 · DOI:10.1016/j.celrep.2016.04.088

MeSH Terms (20)

Allosteric Regulation Amino Acid Sequence Amino Acid Substitution Animals Biological Evolution CREB-Binding Protein DNA-Activated Protein Kinase Forkhead Box Protein O1 HeLa Cells Homeodomain Proteins Humans Intrinsically Disordered Proteins Mice Models, Biological Models, Molecular Phosphorylation Protein Binding Protein Domains Protein Structure, Secondary Transcriptional Activation

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