Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.

Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, Kelly JW
J Am Chem Soc. 2016 138 (23): 7353-64

PMID: 27191344 · PMCID: PMC4909538 · DOI:10.1021/jacs.6b02960

MeSH Terms (13)

Binding Sites Cell Culture Techniques Crystallography, X-Ray Fatty Acid-Binding Proteins Fluorine HeLa Cells Humans Hydrophobic and Hydrophilic Interactions Ligands MCF-7 Cells Receptors, Retinoic Acid Sulfuric Acids Tyrosine

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