Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration.

Panarese JD, Cho HP, Adams JJ, Nance KD, Garcia-Barrantes PM, Chang S, Morrison RD, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2016 26 (15): 3822-5

PMID: 27173801 · PMCID: PMC5082649 · DOI:10.1016/j.bmcl.2016.04.083

MeSH Terms (13)

Allosteric Regulation Animals Central Nervous System Central Nervous System Agents Dose-Response Relationship, Drug Drug Discovery Heterocyclic Compounds Molecular Structure Pyridines Pyrroles Rats Receptor, Muscarinic M1 Structure-Activity Relationship

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