Hydrophobic interactions between polymeric carrier and palmitic acid-conjugated siRNA improve PEGylated polyplex stability and enhance in vivo pharmacokinetics and tumor gene silencing.

Sarett SM, Werfel TA, Chandra I, Jackson MA, Kavanaugh TE, Hattaway ME, Giorgio TD, Duvall CL
Biomaterials. 2016 97: 122-32

PMID: 27163624 · PMCID: PMC4894661 · DOI:10.1016/j.biomaterials.2016.04.017

MeSH Terms (15)

Animals Cell Line, Tumor Drug Carriers Female Gene Silencing Humans Hydrophobic and Hydrophilic Interactions Mice, Nude Neoplasms Palmitic Acid Polyethylene Glycols Polymers Reproducibility of Results RNA, Small Interfering Tissue Distribution

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