Structural Analysis Using Chiroptical Spectroscopy: Insights and Cautions.

Polavarapu PL
Chirality. 2016 28 (6): 445-52

PMID: 27103344 · DOI:10.1002/chir.22601

Chiroptical spectroscopy has evolved into a promising tool for chiral molecular structural determination in the last four decades. Determination of the absolute configurations (ACs) of bromochlorofluoromethane and [(2) H1 ,(2) H2 ,(2) H3 ]-neopentane demonstrated the enviable advantages of chiroptical spectroscopy. Furthermore, uncovering the errors in the ACs reported in the literature established a glimpse of what can be accomplished with the modern chiroptical spectroscopic methods. Despite these triumphs, it is important to exercise caution in the practice of chiroptical spectroscopic methods, because certain widely practiced approaches can lead to erroneous conclusions. Selected major accomplishments and special precautions needed for future applications are emphasized. Chirality 28:445-452, 2016. © 2016 Wiley Periodicals, Inc.

© 2016 Wiley Periodicals, Inc.

MeSH Terms (9)

Circular Dichroism Hydrocarbons, Halogenated Isoflurane Models, Molecular Molecular Structure Pentanes Quantum Theory Spectrum Analysis, Raman Stereoisomerism

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