Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM
Nat Med. 2016 22 (5): 497-505

PMID: 27089513 · PMCID: PMC4860133 · DOI:10.1038/nm.4082

MeSH Terms (26)

Animals Carcinoma, Pancreatic Ductal Chromatography, Liquid Collagen Disease Models, Animal Disease Progression Extracellular Matrix Fibrosis Genotype Humans Integrin beta Chains Mice Microscopy, Atomic Force Mutation Pancreatic Neoplasms Prognosis Proteomics Proto-Oncogene Proteins p21(ras) Real-Time Polymerase Chain Reaction Signal Transduction Smad4 Protein STAT3 Transcription Factor Survival Rate Tandem Mass Spectrometry Transforming Growth Factor beta Tumor Microenvironment

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