Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain.

Vergeade A, Bertram CC, Bikineyeva AT, Zackert WE, Zinkel SS, May JM, Dikalov SI, Roberts LJ, Boutaud O
Mitochondrion. 2016 28: 88-95

PMID: 27085476 · PMCID: PMC4860904 · DOI:10.1016/j.mito.2016.04.002

Modifications of cardiolipin (CL) levels or compositions are associated with changes in mitochondrial function in a wide range of pathologies. We have made the discovery that acetaminophen remodels CL fatty acids composition from tetralinoleoyl to linoleoyltrioleoyl-CL, a remodeling that is associated with decreased mitochondrial respiration. Our data show that CL remodeling causes a shift in electron entry from complex II to the β-oxidation electron transfer flavoprotein quinone oxidoreductase (ETF/QOR) pathway. These data demonstrate that electron entry in the respiratory chain is regulated by CL fatty acid composition and provide proof-of-concept that pharmacological intervention can be used to modify CL composition.

Copyright © 2016 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

MeSH Terms (11)

Acetaminophen Antipyretics Cardiolipins Cell Respiration Cells, Cultured Electron Transport Fatty Acids Humans Mitochondria Myeloid Progenitor Cells Quinones

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