Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4).

Engers DW, Blobaum AL, Gogliotti RD, Cheung YY, Salovich JM, Garcia-Barrantes PM, Daniels JS, Morrison R, Jones CK, Soars MG, Zhuo X, Hurley J, Macor JE, Bronson JJ, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR
ACS Chem Neurosci. 2016 7 (9): 1192-200

PMID: 27075300 · PMCID: PMC5031509 · DOI:10.1021/acschemneuro.6b00035

MeSH Terms (11)

Allosteric Regulation Amides Animals Chromatography, High Pressure Liquid Excitatory Amino Acid Agents Humans Picolinic Acids Pyrazoles Pyridines Receptors, Metabotropic Glutamate Structure-Activity Relationship

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