Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design.

Kwon YD, Georgiev IS, Ofek G, Zhang B, Asokan M, Bailer RT, Bao A, Caruso W, Chen X, Choe M, Druz A, Ko SY, Louder MK, McKee K, O'Dell S, Pegu A, Rudicell RS, Shi W, Wang K, Yang Y, Alger M, Bender MF, Carlton K, Cooper JW, Blinn J, Eudailey J, Lloyd K, Parks R, Alam SM, Haynes BF, Padte NN, Yu J, Ho DD, Huang J, Connors M, Schwartz RM, Mascola JR, Kwong PD
J Virol. 2016 90 (13): 5899-5914

PMID: 27053554 · PMCID: PMC4907239 · DOI:10.1128/JVI.03246-15

MeSH Terms (14)

Animals Antibodies, Neutralizing Chemistry Techniques, Analytical Crystallography, X-Ray Disulfides Half-Life High-Throughput Nucleotide Sequencing HIV-1 HIV Antibodies Humans Hydrophobic and Hydrophilic Interactions Macaca mulatta Models, Molecular Solubility

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