Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 3. Engineering plasma stability by discovery and optimization of isoindolinone analogs.

Garcia-Barrantes PM, Cho HP, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2016 26 (8): 1869-72

PMID: 26988302 · PMCID: PMC4823774 · DOI:10.1016/j.bmcl.2016.03.031

MeSH Terms (14)

Allosteric Regulation Central Nervous System Coumarins Dose-Response Relationship, Drug Drug Discovery Drug Stability Furans Humans Isoindoles Molecular Structure Phthalimides Receptors, Metabotropic Glutamate Structure-Activity Relationship Substrate Specificity

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