Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action.

Hempel JE, Cadar AG, Hong CC
Bioorg Med Chem Lett. 2016 26 (8): 1947-53

PMID: 26976215 · PMCID: PMC5147493 · DOI:10.1016/j.bmcl.2016.03.013

MeSH Terms (12)

Cyclic Nucleotide Phosphodiesterases, Type 4 Dose-Response Relationship, Drug Hedgehog Proteins HEK293 Cells Humans Molecular Structure Phosphodiesterase 4 Inhibitors Pyrimidinones Repressor Proteins Signal Transduction Smoothened Receptor Structure-Activity Relationship

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