p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.

Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I
Nat Med. 2016 22 (4): 412-20

PMID: 26950362 · PMCID: PMC5546206 · DOI:10.1038/nm.4054

MeSH Terms (16)

Aging Animals Cell Proliferation Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 Fibroblasts Gene Expression Regulation Glucose Humans Insulin Insulin-Secreting Cells Insulin Secretion Mice Mice, Transgenic PPAR gamma TOR Serine-Threonine Kinases

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