Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions.

Liou GY, Döppler H, DelGiorno KE, Zhang L, Leitges M, Crawford HC, Murphy MP, Storz P
Cell Rep. 2016 14 (10): 2325-36

PMID: 26947075 · PMCID: PMC4794374 · DOI:10.1016/j.celrep.2016.02.029

MeSH Terms (21)

Acinar Cells ADAM17 Protein Animals Cells, Cultured Epidermal Growth Factor ErbB Receptors Humans Ligands Mice Mitochondria Mutagenesis, Site-Directed NF-kappa B p52 Subunit Oxidative Stress Pancreatic Neoplasms Precancerous Conditions Protein Kinase C Proto-Oncogene Proteins p21(ras) Reactive Oxygen Species RNA Interference Signal Transduction Up-Regulation

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