mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.

Gogliotti RG, Senter RK, Rook JM, Ghoshal A, Zamorano R, Malosh C, Stauffer SR, Bridges TM, Bartolome JM, Daniels JS, Jones CK, Lindsley CW, Conn PJ, Niswender CM
Hum Mol Genet. 2016 25 (10): 1990-2004

PMID: 26936821 · PMCID: PMC5062588 · DOI:10.1093/hmg/ddw074

MeSH Terms (23)

Adult Allosteric Regulation Animals Autistic Disorder Autopsy Disease Models, Animal Female Gene Expression Regulation Hippocampus Humans Male Methyl-CpG-Binding Protein 2 Mice Mice, Knockout Motor Cortex Neuronal Plasticity Pyrazoles Pyrimidinones Receptor, Metabotropic Glutamate 5 Rett Syndrome Seizures Signal Transduction Young Adult

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