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Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and nuclear inositide metabolism.

Malabanan MM, Blind RD
Biochem Soc Trans. 2016 44 (1): 279-85

PMID: 26862216 · PMCID: PMC5380233 · DOI:10.1042/BST20150225

Inositol polyphosphate multikinase (IPMK, ipk2, Arg(82), ArgRIII) is an inositide kinase with unusually flexible substrate specificity and the capacity to partake in many functional protein-protein interactions (PPIs). By merging these two activities, IPMK is able to execute gene regulatory functions that are very unique and only now beginning to be recognized. In this short review, we present a brief history of IPMK, describe the structural biology of the enzyme and highlight a few recent discoveries that have shed more light on the role IPMK plays in inositide metabolism, nuclear signalling and transcriptional regulation.

© 2016 Authors; published by Portland Press Limited.

MeSH Terms (8)

Animals Biocatalysis Cell Nucleus Gene Expression Regulation Humans Inositol Phosphotransferases (Alcohol Group Acceptor) Transcription, Genetic

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