Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers.

Lee JB, Wang X, Faley S, Baer B, Balikov DA, Sung HJ, Bellan LM
Adv Healthc Mater. 2016 5 (7): 781-5

PMID: 26844941 · PMCID: PMC4828275 · DOI:10.1002/adhm.201500792

A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N-isopropylacrylamide) microfibers. The capillary-like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

MeSH Terms (12)

Acrylic Resins Dermis Fibroblasts Gelatin Humans Hydrogels Imaging, Three-Dimensional Infant, Newborn Microscopy, Confocal Microvessels Perfusion Temperature

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