Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 2: SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool.

Garcia-Barrantes PM, Cho HP, Metts AM, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2016 26 (3): 751-756

PMID: 26778256 · PMCID: PMC4794757 · DOI:10.1016/j.bmcl.2015.12.104

MeSH Terms (13)

Allosteric Regulation Animals Antipsychotic Agents Coumarins Furans Half-Life Heterocyclic Compounds Humans Protein Binding Rats Receptors, Metabotropic Glutamate Schizophrenia Structure-Activity Relationship

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